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companying left-hemisphere lesions; subsequent empirical investigations have supported the tendency for catastrophic reactions and depression to be more associated with left- than right-hemispheric damage (e.g., Gainotti, 1972; Gasparrini, Satz, Heilman, & Coolidge, 1977). Depression, a common side effect of lefthemisphere damage, is often accompanied by numerous clinical presenting symptoms. These include depressed mood and agitation;...psychomotor retardation; impaired immediate memory and learning abilities; defective attention, concentration, and tracking; impaired orientation; an overall shoddy quality to cognitive products; and listlessness with loss of interest in one s surroundings (Lezak, 1995, p. 327). Caine (1986), summarizing literature on depressed patients, stressed their impairments in sustaining attention, memory, learning ability, mental control, and motor performance. Based on these presenting clinical symptoms, it is not surprising that [d]epressed people often have distinctly higher Verbal [than Performance] IQs (Gregory, 1987, p. 72). Gass and Russell (1985) studied the relationship of emotional adjustment (MMPI profile) to functional loss (WAIS Verbal IQ) in a study of 31 Caucasian male patients with carefully documented left-hemisphere damage. These investigators were critical of previous investigations of the emotional behavior in patients with leftbrain lesions because of failure to control for premorbid status, to exclude aphasics, to exclude patients with right-hemisphere pathology, and to screen for inconsistent MMPI profiles. Gass and Russell (1985) used state-of-the-art neurodiagnostic techniques to ensure that the patients lesions were confined to the left hemisphere; they also controlled for education level in their multivariate data analysis. Their results showed that, regardless of the degree of impairment in verbal intelligence, the patients with right lesions consistently had MMPI profiles suggestive of the following emotional symptoms: mild dysphoria, worry, and concerns or preoccupations with regard to one s physical condition (p. 669). The implications of the left-lesion

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patients MMPI emotional profiles are quite consistent with the stereotypical behaviors described previously for these patients. Patients with Right Lesions Patients with right-hemisphere damage typically have different emotional reactions than those with left lesions. The depression that accompanies left lesions can be simulated by inactivating the left hemisphere via the Wada technique, i.e., intracarotid injections of sodium amytal; in contrast, inactivation of the right hemisphere by this technique is likely to produce euphoria (Nebes, 1978). Also, With left hemisphere damaged patients, depression seems to reflect awareness of deficit;...[w]hen the lesion is on the right, the emotional disturbance does not seem to arise from awareness of defects so much as from the secondary effects of the patient s diminished selfawareness and social insensitivity.... Depression in patients with right-sided cortical damage may take longer to develop than it does in patients with left hemisphere involvement[;]...however, it can be more chronic, more debilitating, and more resistive to intervention (Lezak, 1995, p. 68). The inappropriate indifference of right-lesion patients was first stressed in the early 1950s (Denny-Brown, Meyer, & Horenstein, 1952; Hecaen, Ajuriaguerra, & Massonet, 1951). This indifference was observed by Gainotti (1972) in patients with right damage, just as the catastrophic reaction was observed in left-damaged patients, in a study of 160 individuals with lateralized lesions. Whereas Gainotti considered the profound depression of patients with left lesions to be a normal response to severe cognitive deficits, he felt the indifference reaction was an abnormal mood associated with denial of illness (Valenstein & Heilman, 1979, p. 425). In a study of 50 Caucasian male patients with right-hemisphere damage, Gass and Russell (1987) studied the relationship of emotional adjustment (MMPI profile) to functional loss (WAIS Performance IQ); this investigation was analogous to these authors similar study, described previously, of patients with left lesions

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(Gass & Russell, 1985). Gass and Russell (1987) again used sophisticated neurodiagnostic techniques and controlled for age and education level in their multivariate data analysis. Their results showed that, regardless of the degree of impairment in nonverbal intelligence, the patients with right lesions consistently had MMPI profiles suggestive of the following emotional symptoms: mildly depressed, pessimistic, and worried; discouraged and lacking initiative; somatic preoccupation; denial; and limited emotional insight. This profile sounds fairly consistent with clinical observations of right-lesion patients, but interpretation is hampered by the investigators failure to report the degree of chronicity of the subjects lesions, or to control for this important variable. Even more consistent with the indifference and denial of right-lesion patients were the results of a creative study conducted by Anderson and Tranel (1989). They investigated 100 braindamaged patients awareness of their own cognitive deficits, as measured by a neuropsychological battery that included the WAIS-R. This sample included 32 acute stroke victims with lesions lateralized to the left (N = 12) or right (N = 20) hemisphere. Nearly all (90%) of the rightlesion patients demonstrated unawareness of cognitive deficits in intelligence, memory, or other areas, and five patients with right lesions with substantial paralysis even denied having motor problems. Significantly fewer (41%) of the patients with left lesions evidenced unawareness of a cognitive deficit; none of these patients with partial paralysis denied having motor difficulties. Clinical Applications of the Emotional Component of Brain Damage The generally different, predictable affective responses to damage to the left or right hemispheres must be taken into account when interpreting the V P discrepancy studies involving patients with unilateral brain damage. The emotional behaviors accompanying left lesions, most notably anxiety, depression, carelessness, and low energy level, are likely to have their most significant impact on Wechsler s Perfor-

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